We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

BACKGROUND: Hallucinations and delusions that complicate Parkinson’s disease could lead to nursing home placement and are linked to increased mortality. Cognitive impairments are typically associated with the presence of hallucinations but there are no data regarding whether such a relationship exists with delusions. OBJECTIVE: We hypothesized that hallucinations would be associated with executive and visuospatial disturbance. An exploratory examination of cognitive correlates of delusions was also completed to address the question of whether they differ from hallucinations. METHODS: 144 PD subjects (...) completed a neuropsychological battery to assess cognition and the SAPS to examine psychosis. Correlational analyses assessed associations between hallucinations and delusions with cognitive domains. RESULTS: 48 subjects reported psychotic symptoms: 25 experienced hallucinations without delusions, 23 had symptoms dominated by delusions. Severity and/or number of hallucination subtypes were significantly correlated with lower scores in language, memory, attention, executive functioning, and visuospatial ability. Correlations with delusions were non-significant. Tests of differences in the size of the correlations between groups revealed a significant relationship between language and visuospatial performance with hallucinations. CONCLUSIONS: Cognitive correlates of hallucinations and delusions appear to be different in PD, suggesting distinct pathogenic mechanisms and possibly anatomical substrates. Hence, delusions may not share the same associations with dementia as hallucinations. Since this is a new finding, further studies will be needed to confirm our results. (shrink)

To date the teaching of business ethics has been examined from the descriptive, prescriptive, and analytical perspectives. The descriptive perspective has reviewed the existence of ethics courses (e.g., Schoenfeldtet al., 1991; Bassiry, 1990; Mahoney, 1990; Singh, 1989), their historical development (e.g., Sims and Sims, 1991), and the format and syllabi of ethics courses (e.g., Hoffman and Moore, 1982). Alternatively, the prescriptive literature has centred on the pedagogical issues of teaching ethics (e.g., Hunt and Bullis, 1991; Strong and Hoffman, 1990; Reeves, (...) 1990; Castro, 1989; George, 1987; Golenet al., 1985) and in providing recommendations for teachers of business ethics (e.g., Nappi, 1990; Hosmer and Steneck, 1989). From the analytical perspective judgments have been made as to whether courses in ethics are in fact effective in achieving value and attitudinal modifications in students (e.g., Loeb, 1991; Weber, 1990; Wynd and Mager, 1989; Pamental, 1989; Martin, 1982; Purcell, 1977). The evidence to date suggests that courses can be a means of achieving ethical awareness and sensitivity in students although it should be recognized that significant objections to the teaching of business ethics do exist and greatly inhibit their successful introduction. This paper addresses a number of the common objections to the teaching of business ethics that must be overcome if ethical programs are to continue in the future, and concludes with recommendations to facilitate the establishment of ethical training in an academic context. (shrink)

We apply an online optimization process based on machine learning to the production of Bose-Einstein condensates. BEC is typically created with an exponential evaporation ramp that is optimal for ergodic dynamics with two-body s-wave interactions and no other loss rates, but likely sub-optimal for real experiments. Through repeated machine-controlled scientific experimentation and observations our ’learner’ discovers an optimal evaporation ramp for BEC production. In contrast to previous work, our learner uses a Gaussian process to develop a statistical model of the (...) relationship between the parameters it controls and the quality of the BEC produced. We demonstrate that the Gaussian process machine learner is able to discover a ramp that produces high quality BECs in 10 times fewer iterations than a previously used online optimization technique. Furthermore, we show the internal model developed can be used to determine which parameters are essential in BEC creation and which are unimportant, providing insight into the optimization process of the system. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

We start with a nearly arbitrary standard classical first order "language" $C\sb{o},$ which is expanded to $C\sb{M,T}$ = "$C\sb{o}+M+T$", where for any variable x, M and T are unary formulas. We start also with a model ${\cal T}\sb{o},$ which together with $C\sb{o}$ represents a fixed non-problematic interpreted first order language. For each $\mu,\tau\subseteq U\sb{o},$ the universe of discourse for ${\cal T}\sb{o},$ the model ${\cal T}\sb{\mu,\tau}$ over $C\sb{M,T}$ is given so that its reduct to $C\sb{o}$ is just ${\cal T}\sb{o},$ and so (...) that for any $C\sb{M,T}$-variable x, the set-extensions of M and T are $\mu$ and $\tau$ respectively. For each $C\sb{M,T}$-expression e, $\vec e$ is its distinctly chosen representative in $U\sb{o},$ and $\lbrack\!\lbrack e\rbrack\!\rbrack$ is a constant $C\sb{o}$-term which names $\vec e.$ ;The goal is to find $\mu\sb*$ and $\tau\sb*,$ such that $\mu\sb*$ and $\tau\sb*$ plausibly and "self-referentially" approximate meaningfulness and truth respectively for any interpreted language represented by ${\cal T}\sb{\mu\sb*,\tau\sb*},$ by satisfying at least the following conditions. ; $\tau\sb*\subseteq\mu\sb*,$ and for each $C\sb{M,T}$-sentence $\sigma$ such that ${\cal T}\sb{\mu\sb*,\tau\sb*}\models M\lbrack\!\lbrack\sigma\rbrack\!\rbrack,$ $$\eqalign{&\ {\cal T}\sb{\mu\sb*,\tau\sb*} \models\sigma\Longleftrightarrow{\cal T}\sb{\mu\sb*,\tau\sb*}\models T\lbrack\!\lbrack\sigma\rbrack\!\rbrack,\ {\rm and}\cr&\ {\cal T}\sb{\mu\sb*,\tau\sb*}\models T\lbrack\!\lbrack\sigma\\leftrightarrow T\lbrack\!\lbrack\sigma\rbrack\!\rbrack\rbrack\!\rbrack.\cr}$$ ; There is a class of expression representatives $\mu\sp{D}\subseteq\mu\sb*$ containing every $C\sb{o}$-expression representative, such that the set $\tau\sp{D}=\mu\sp{D}\ \cap\ \tau\sb*$ itself satisfies the following properties. ;First, for each $\vec\sigma$ such that $\sigma$ is a $C\sb{M,T}$-sentence, if for all $\mu,\tau\subseteq U\sb{o}$ satisfying $\mu\supseteq\mu\sb*$ and $\tau\supseteq\tau\sp{D},$ it is the case that ${\cal T}\sb{\mu,\tau}\models\sigma,$ then $\vec\sigma\in\tau\sp{D}.$ ;Second, whenever $\vec\sigma\in\tau\sp{D},$ then also $\sp{\vec{\enspace}}\ \in\tau\sp{D}.$ ;Third, $\tau\sp{D}$ is "upwardly closed" with respect to the strong-Kleene rules for the truth-value evaluation of Boolean combinations of formulas. For example, for $C\sb{M,T}$-sentences $e\sb1$ and $e\sb2$: $$\eqalign{&\ \vec e\sb1\in\tau\sp{D}\Longleftrightarrow)\sp{\vec{\enspace}}\ \in\tau\sp{D}.\cr&\ {\rm If}\ \vec e\sb1\in\tau\sp{D}\ {\rm or}\ \vec e\sb2\in\tau\sp{D},\ {\rm then\ so\ is}\ \sp{\vec{\enspace}}\ \in\tau\sp{D}.\cr&\ {\rm If}\ \sp{\vec{\enspace}}\ \in\tau\sp{D}\ {\rm and}\ \sp{\vec{\enspace}}\ \in\tau\sp{D},\ {\rm then}\ )\sp{\vec{\enspace}}\ \in\tau\sp{D}.\cr}$$ ; For each $C\sb{M,T}$-expression e not involving T, ${\cal T}\sb{\mu\sb*,\tau\sb*}\models M\lbrack\!\lbrack e\rbrack\!\rbrack$; in particular, for any $C\sb{M,T}$-expression e whatsoever, ${\cal T}\sb{\mu\sb*,\tau\sb*}\models M\lbrack\!\lbrack\\neg M\lbrack\!\lbrack e\rbrack\!\rbrack\rbrack\!\rbrack.$ ; ;In this dissertation, it is shown for the first time that there are in fact $\mu\sb*$ and $\tau\sb*$ which simultaneously satisfy all three conditions , , and , even when the consequent of the Godel fixed point theorem must hold. (shrink)

The topic of this thesis is how different phenomena, commonly regarded as "psychological" or "mental", are or can be apprehended in the first person. The aim is to show that a number of influential texts of contemporary philosophy display a particular type of oversight on this topic. The texts in question display, I argue, an insufficient appreciation of the case for holding that "non-qualitative" psychological phenomena are apprehended in an exclusive way in the first person. To make this case, I (...) begin by isolating a limited class of phenomena. The class, which is called the class of 'occurrent psychological doings', includes performances such as searching for a flower and adding two numbers. In chapter 2, I submit a case for holding that it is logically necessary that if an agent is performing an occurrent psychological doing, then he has a certain apprehension of what he is doing. This claim is called The First-Person Thesis'. In chapter 3, I submit a case for holding that the type of apprehension mentioned in The First-Person Thesis is logically exclusive: it is an apprehension which an agent who is doing so-and-so can have of the fact that he is doing so-and-so but which it is logically impossible for someone else to have of this fact. This claim is called 'The Exclusiveness Thesis'. In chapters 4 and 5, the two theses are used in critical discussions of some influential texts of contemporary philosophy. In chapter 4,1 examine two arguments of Wittgenstein's to the effect that one may perform some selected actions without having a particular type of "experience", or "sensation". I try to show that these arguments, while valid, have rather limited implications. I use The First-Person Thesis to illustrate the limited scope of these implications. I then try to show that the limited significance of the arguments has often been obscured by commentators of Wittgenstein. In chapter 5, I examine a position commonly held in contemporary philosophy of mind, and often associated with Nagel. The position is that "qualitative" phenomena such as perceptual experiences and bodily sensations are, because of the appearances they present in the first person, particularly difficult to explain in physical terms. An implication of this view is the claim that other phenomena do not present appearances to subjects in the allegedly problematic way that "qualitative" phenomena do. The First-Person Thesis and The Exclusiveness Thesis are used to argue that this position, as exemplified in the writings of McGinn and Chalmers, involve controversial assumptions for which insufficient justification is provided. (shrink)

Moral theories which, like those of Plato, Aristotle and Aquinas, give a central place to the virtues, tend to assume that as traits of character the virtues are mutually compatible so that it is possible for one and the same person to possess them all. This assumption—let us call it the compatibility thesis—does not deny the existence of painful moral dilemmas: it allows that the virtues may conflict in particular situations when considerations associated with different virtues favour incompatible courses of (...) action, but holds that these conflicts occur only at the level of individual actions. Thus while it may not always be possible to do both what would be just and what would be kind or to act both loyally and honestly, it is possible to be both a kind and a just person and to have both the virtue of loyalty and the virtue of honesty. (shrink)

This volume commemorates the 6th centennial of the birth of Nicholas of Cusa (1401-1464), a Renaissance polymath whose interests included law, politics, metaphysics, epistemology, theology, mysticism and relations between Christians and non-Christian peoples. The contributors to this volume reflect Cusanus' multiple interests; and, by doing so they commemorate three deceased luminaries of the American Cusanus Society: F. Edward Cranz, Thomas P. McTighe and Charles Trinkaus. Contributors include: Christopher M. Bellitto, H. Lawrence Bond, Elizabeth Brient, Louis Dupré, Wilhelm Dupré, Walter Andreas (...) Euler, Lawrence Hundersmarck, Thomas M. Izbicki, Dennis D. Martin, Yelena Matusevich, Bernard McGinn, Clyde Lee Miller, Thomas E. Morrissey, Brian A. Pavlac, and Morimichi Watanabe. Publications by Charles Trinkaus: - Edited by C. Trinkaus and H.A. Oberman, The pursuit of holiness in late medieval and renaissance religion, ISBN: 978 90 04 03791 5 (Out of print). (shrink)

In this important study D. M. Armstrong offers a comprehensive system of analytical metaphysics that synthesises but also develops his thinking over the last twenty years. Armstrong's analysis, which acknowledges the 'logical atomism' of Russell and Wittgenstein, makes facts the fundamental constituents of the world, examining properties, relations, numbers, classes, possibility and necessity, dispositions, causes and laws. All these, it is argued, find their place and can be understood inside a scheme of states of affairs. This is a comprehensive and (...) rigorously this-worldly account of the most general features of reality, argued from a distinctive philosophical perspective, and it will appeal to a wide readership in analytical philosophy. (shrink)

The central insight of Darwin's Origin of Species is that evolution is an ecological phenomenon, arising from the activities of organisms in the 'struggle for life'. By contrast, the Modern Synthesis theory of evolution, which rose to prominence in the twentieth century, presents evolution as a fundamentally molecular phenomenon, occurring in populations of sub-organismal entities - genes. After nearly a century of success, the Modern Synthesis theory is now being challenged by empirical advances in the study of organismal development and (...) inheritance. In this important study, D. M. Walsh shows that the principal defect of the Modern Synthesis resides in its rejection of Darwin's organismal perspective, and argues for 'situated Darwinism': an alternative, organism-centred conception of evolution that prioritises organisms as adaptive agents. His book will be of interest to scholars and advanced students of evolutionary biology and the philosophy of biology. (shrink)

Plotinus is the first Greek philosopher to hold a systematic theory of consciousness. The key feature of his theory is that it involves multiple layers of experience: different layers of consciousness occur in different levels of self. This layering of higher modes of consciousness on lower ones provides human beings with a rich experiential world, and enables human beings to draw on their own experience to investigate their true self and the nature of reality. This involves a robust notion of (...) subjectivity. However, it is a notion of subjectivity that is unique to Plotinus, and remarkably different from the Post-Cartesian tradition. Behind the plurality of terms Plotinus uses to express consciousness, and behind the plurality of entities to which Plotinus attributes consciousness, lies a theory of human consciousness. It is a Platonist theory shaped by engagement with rival schools of ancient thought. (shrink)

Truths are determined not by what we believe, but by the way the world is. Or so realists about truth believe. Philosophers call such theories correspondence theories of truth. Truthmaking theory, which now has many adherents among contemporary philosophers, is the most recent development of a realist theory of truth, and in this book D. M. Armstrong offers the first full-length study of this theory. He examines its applications to different sorts of truth, including contingent truths, modal truths, truths about (...) the past and the future, and mathematical truths. In a clear, even-handed and non-technical discussion he makes a compelling case for truthmaking and its importance in philosophy. His book marks a significant contribution to the debate and will be of interest to a wide range of readers working in analytical philosophy. (shrink)

In this important study D. M. Armstrong offers a comprehensive system of analytical metaphysics that synthesises but also develops his thinking over the last twenty years. Armstrong's analysis, which acknowledges the 'logical atomism' of Russell and Wittgenstein, makes facts the fundamental constituents of the world, examining properties, relations, numbers, classes, possibility and necessity, dispositions, causes and laws. All these, it is argued, find their place and can be understood inside a scheme of states of affairs. This is a comprehensive and (...) rigorously this-worldly account of the most general features of reality, argued from a distinctive philosophical perspective, and it will appeal to a wide readership in analytical philosophy. (shrink)

tome I. Absolute to Church -- tome II. Classicism to enthusiasm -- tome III. Envy to incognito -- tome IV. Individual to novel -- tome V. Objectivity to sacrifice --tome VI. Salvation to writing.

According to historical theories of biological function, a trait's function is determined by natural selection in the past. I argue that, in addition to historical functions, ahistorical functions ought to be recognized. I propose a theory of biological function which accommodates both. The function of a trait is the way it contributes to fitness and fitness can only be determined relative to a selective regime. Therefore, the function of a trait can only be specified relative to a selective regime. Apart (...) from its desirable pluralism, only this view of relational function can support the function/accident and function/malfunction distinctions commonly thought to be part of the concept of function. Furthermore, only relational function correctly characterizes the explanatory consequences of function attributions in evolutionary biology. (shrink)

This collection of original essays covers a wide range of issues in current naturalised philosophy of mind. Particular attention is paid to the ways in which concepts drawn from evolutionary biology might enhance our understanding of the place of mind in the natural world. Issues covered include the advantages of construing the mind as an adaptation, the naturalisation of intentional and phenomenal content, the evolution of means-end reasoning, rationality and higher-order intentionality, methodological issues in cognitive ethology and evolutionary psychology.

Kierkegaard's Concepts is a comprehensive, multi-volume survey of the key concepts and categories that inform Kierkegaard's writings. Each article is a substantial, original piece of scholarship, which discusses the etymology and lexical meaning of the relevant Danish term, traces the development of the concept over the course of the authorship, and explains how it functions in the wider context of Kierkegaard's thought. Concepts have been selected on the basis of their importance for Kierkegaard's contributions to philosophy, theology, the social sciences, (...) literature and aesthetics, thereby making this volume an ideal reference work for students and scholars in a wide range of disciplines. (shrink)

Using 94 published empirical articles in academic journals as a data base, this paper provides a critical review of the methodology employed in the study of ethical beliefs and behavior of organizational members. The review revealed that full methodological detail was provided in less than one half of the articles. Further, the majority of empirical research articles expressed no concern for the reliability or validity of measures, were characterized by low response rates, used convenience samples, and did not offer a (...) theoretic framework, hypotheses, or a definition of ethics. Several recommendations, including a reviewer rating form addressing methodological decisions and inclusion of methodologists on the review panel, are offered to improve methodological rigor in published ethics research. (shrink)

In this short text, a distinguished philosopher turns his attention to one of the oldest and most fundamental philosophical problems of all: How it is that we are able to sort and classify different things as being of the same natural class? Professor Armstrong carefully sets out six major theories—ancient, modern, and contemporary—and assesses the strengths and weaknesses of each. Recognizing that there are no final victories or defeats in metaphysics, Armstrong nonetheless defends a traditional account of universals as the (...) most satisfactory theory we have.This study is written for advanced students, but as Armstrong goes considerably beyond his earlier work on this topic, it will interest professional scholars as well. Carefully plotted and clearly written, Universals is both a paradigm of exposition and a case study on the value of careful analysis of fundamental issues in philosophy. (shrink)

The most compelling extant accounts of explanation casts all explanations as causal. Yet there are sciences, theoretical population biology in particular, that explain their phenomena by appeal to statistical, non-causal properties of ensembles. I develop a generalised account of explanation. An explanation serves two functions: metaphysical and cognitive. The metaphysical function is discharged by identifying a counterfactually robust invariance relation between explanans event and explanandum. The cognitive function is discharged by providing an appropriate description of this relation. I offer examples (...) of explanations from portfolio theory and population genetics that meet this characterisation. In each case the invariance relation holds between a statistical property of an ensemble and a change in structure of the ensemble. In neither case, however, does the statistical property cause the outcome it explains. There are genuine statistical, non-causal scientific explanations. (shrink)